Jaundice is characterised by elevated blood bilirubin levels. In conjunction with other liver function tests, it is used to determine the degree of any intrahepatic or extrahepatic blockage. It is a sign of cholestasis. Raised ALP and GGT, both of which indicate cholestasis, are frequently found in conjunction with raised direct bilirubin. Neonatal kernicterus is caused by the buildup of free, unconjugated bilirubin in areas of the brain that have crossed the blood-brain barrier. This irreversible damage to those areas manifests as a variety of neurological impairments, seizures, aberrant reflexes, and abnormal eye movements.