Bone profile blood test
Normal Reference Range
ALP:
0 – 0.5 yrs = 57 – 265U/L
0.5 – 10 yrs = 100 – 360U/L
10 – 17 yrs = 100 – 450U/L
>17 yrs = 25 – 115U/L
Calcium/ Corrected Calcium:
2.2 – 2.6mmol/L
Albumin:
38 – 50 g/L
Phosphate:
0 – 2 Days = 1.4 – 2.8mmol/L
2 Days – 12 yrs = 1.3 – 2.1mmol/L
12 – 20 yrs = 1.1 – 2.0mmol/L
>20 yrs = 0.8 – 1.4mmol/L
Magnesium:
0.7 – 1.0 mmol/L
Test Information
The bone profile also includes the ALP assay, albumin, phosphate, magnesium, and ionisable calcium.
The ratio of bound to unbound calcium can be more easily estimated via albumin measurement since inorganic phosphate and calcium concentrations are related to bone formation and resorption. Only unbound (ionised) calcium is accessible for cellular action. For clinical diagnosis and treatment, using corrected calcium levels is advised.
Important: Patients with very low albumin levels (20 g/L) should have their ionised calcium levels measured using blood gas analysers rather than serum total calcium readings since a corrected calcium level cannot be calculated using the conventional method based on albumin level.
The ALP assay serves as a measure of osteoblastic and osteoclast-mediated bone turnover.
Clinical Indications
Assessment suspected bone disease: Osteoporosis, Parathyroid disorders and osteolytic lesions secondary to metastasis.
Sample Required
5mL serum sample blood tube is required for bone profile blood test
Min. sample volume
0.5mL
Special Instructions and Precautions
Not applicable
Time Limits For Retrospective Testing
2 days
Any factors affecting the test
Not applicable
Turnaround Time
4 hrs
Referral centre (if applicable)
Not applicable
Test Code
BONE