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Alpha-1 antitrypsin blood test
*Advise phenotype assay for apparent deficiency
Normal Reference Range
1.1 – 2.1g/L*
Test Information
Familial A1AT deficiency leads to predominantly unrestricted proliferation of neutrophil-mediated elastase in the tissues of the lung causing extensive collateral damage and subsequent emphysema-like symptoms in adults. Alternatively, neonatal accumulation of dysfunctional A1AT in the liver causes the production of abnormal polymers that damage the surrounding tissues of the liver.
Clinical Indications
• Unexplained liver cirrhosis in juveniles (and rarely adults.)
• Suspected early-onset emphysema (juveniles/ adults) or emphysema with/without F/H
• Observed deficiency as seen on routine Serum protein electrophoresis investigation.
Sample Required
5mL serum sample tube is required for A1AT blood test
Min. sample volume
0.5mL
Special Instructions and Precautions
Not applicable
Time Limits For Retrospective Testing
5 days
Any factors affecting the test
Not applicable
Turnaround Time
4 hrs
Referral centre (if applicable)
Not applicable
Test Code
A1AT